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| The HIV/AIDS eNews is published by the British Columbia Persons With AIDS Society. This publication is a compilation of various articles collected from various news sources. Opinions and information expressed are those of the individual authors and not necessarily those of the Society. |
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Loon Lake Camp 2008
A healing retreat for people living with HIV June 23rd to 26th and September 2nd to 5th
For more information or to schedule an interview, call 1.800.994.2437 ext.200
[ Map ] |
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Need Helpful Information?
Check out BCPWA’s Advocacy Action Kits
Advocacy Action Kits offer up-to-date information on welfare, seniors and current advocacy issues for persons with disabilities. The info sheets offer a simple, step-by-step approach, with downloadable forms for your convenience.
[ Advocacy Action Kits ] |
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Volunteer Need for New Workshop Series
BCPWA is in the process of developing a Newly Diagnosed Workshop Series [NDWS] for Gay Men and we need a volunteer to sit in our working group for the design, development and implementation of the NDWS. Time commitments are flexible but we are hoping to meet up to once a week over the next three to six months.
Ideally, this volunteer will be less than two years diagnosed and have strong facilitation skills. Good communication skills and possible health care background would also be an asset. Most importantly, we require someone who is going through (or has recently gone through) the newly diagnosed experience.
For more information, please contact Marc S. (BCPWA Coordinator of Volunteers and Training) at 604 893 2298 or marcs@bcpwa.org or Elgin Lim (BCPWA Director of Prevention) at 604-893-2225 or elginl@bcpwa.org. |
This Week’s Topic: Will there ever be an AIDS vaccine?
Or are we chasing a ghost?
[ Comment Now! ]
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Local & National News
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Turmoil Deepens in AIDS Funding Crunch
Service groups kept in dark about fed HIV funding
April 22, 2008
"It's like constantly wondering, 'What are we going to do?'" says John McTavish
from Kingston, speaking about planning AIDS prevention programs. "You wonder,
'what's next?' You're always trying to think ahead, to what we should be
doing in the future."
But that's just gotten a lot more complicated, says McTavish, the director
of HIV/AIDS Regional Services for Kingston (HARS). He doesn't know what AIDS
programming will be available to residents there a year from now.
That's because service groups across the country are being kept in the dark
about what the federal government's contribution to their programming will
look like past March 2009.
HARS has two part-time employees working on HIV prevention and education,
both sponsored by the feds. They give out important health information to
high-risk youth, the gay community, and others.
"It's hard to keep your staff and for them to want to commit," says McTavish.
"Stress level goes up — for not just of those staff, but for all the staff.
So you have turnover, and then you have to begin all over again."
Brian Lester agrees. He heads up prevention work at the AIDS Committee of
London. There, the federal programming pays for one full-time employee to
run education campaigns in bathhouses, bars and in gay chatrooms online.
"That money helped us dedicate resources to the gay-bi-MSM community," says
Lester. "We would lose our capacity to do the extensive outreach we do."
In Canada, the provinces typically pay for AIDS groups' core funding. The
community, through fundraising, pays for most of the service delivery. The
feds kick in for HIV prevention, education and some support work.
Or they have, historically.
There are less than 11 months of federal AIDS cash remaining. Last month,
the clock ran out on federal funding for hepatitis C work. It has yet to
be replaced.
It serves as a chilling precedent. It also means that AIDS groups, which
often provide hep C programming, are already feeling the pinch.
HARS received federal hep C money "off and on" over the last five years.
It has always been "piecemeal," says McTavish.
"We have people living with hep C coming through our office every week. Especially
when it comes to services, we don't want to say, 'No we can't help you,'"
he says.
And in Kingston, "we don't have anywhere else to send them," says McTavish.
"We may have been the only game in town for hep C," he says. "Whereas in
larger urban centres, there may have been other people doing the work or
a little bit of the work."
McTavish may see hep C money again. But that uncertainty makes planning difficult.
Elsewhere, groups like the Toronto-based Africans in Partnership Against
AIDS still haven't heard if money is coming in between now and March 2009.
"We submitted a request and are still waiting for a response," says Fanta
Ongoiba, the program's director, in an email to Capital Xtra. "I know that
some agencies have already received their approval letter and some not yet.
So we don't know if it has been approved or not."
Historically, funding has been issued in four-year blocks. But since the
Conservative Party took the helm, they have simply extended existing funding
in six-month and one-year increments. The result is perpetual uncertainty
for groups that receive funding — and no opportunity for new groups to apply.

The problems are magnified for AIDS Service Organizations (ASOs) in areas
that are rapidly growing. Durham Region is growing by 10 percent every five
years. It's home to some of Ontario's quickest expansion — between 2001 and
2006, the city of Whitby grew by over 27 percent. Some estimates suggest
Durham region will double in population by 2020.
AIDS Durham has been shut out of federal funding since 2000. Peter Richtig
is the director.
"That's part of the problem," says Richtig. "But there's never been an adequate
pool of money for AIDS organizations, so it's incredibly competitive. Emerging
agencies don't have that kind of staff and they don't have the capacity to
jump through all the hoops."
"We're the only people providing unconditional support, and we're out panhandling
in the community when we should be in the office with clients," he says.
It's an even more bitter pill to swallow because the envelope was supposed
to get bigger in 2007, not smaller. For Ontario, $1 million in promised additional
federal funding was yanked in 2007, with a further $1 million of promised
money gone for 2008-2009. By 2012, the federal funding envelope will be $7
million smaller.
Murray Jose is from PWA Toronto. Like in Kingston, PWA Toronto's federal
money runs out next March.
"Many organizations that were not successful in the last grant application
round have had no opportunity to re apply and get federal funding — so there
is huge disparity between ASOs," says Jose.
"We would have applied and been able to create new programs or adjust our
work to most effectively respond to changing needs of our clients."
As for the Public Health Agency of Canada (PHAC), they're keeping their cards
close to their chest. On hep C funding, they've committed to renewing their
contributions later this year. But they're silent about community AIDS programming.
"We continue to work with community organizations that make a positive impact
on addressing the hepatitis C epidemic in Canada, and we look forward to
supporting more community projects on a national and regional scale," says
PHAC's Phillipe Brideau in a written statement to Capital Xtra.
He says that in 2007-08, the "main focus" of hep C spending was on "strategic
planning," including meetings with service providers across the country.
"We are anticipating announcing our planned approach in the coming weeks,"
he continues. "We realize that community organizations have been waiting
for some time to hear news of federal funding, and we are optimistic that
our renewed approach will provide our partners with the support they need."
But with AIDS funding, they won't even say what the shape of the review looks
like.
"As for the overall Grants and Contributions fiscal review, final decisions
have not yet been made on the budget levels," he writes.
Groups in Ontario, Quebec and Alberta are fighting back. Last month, the
Ontario AIDS Network started a postcard campaign, calling on the Conservative
government to restore funding to promised levels.
They've also launched a national website, increasedAIDSfunding.ca.
The message to politicians is that cash promised in 2005 needs to be delivered,
says Rick Kennedy, director of the Ontario AIDS Network.
That would mean increasing federal contributions to ASOs to $13.9 million
in Canada, or $4.5 million for Ontario.
"They've never said that the money is not necessary or not needed," says
Kennedy. "They've only said that they can't afford it because of across-the-board
cuts to PHAC. We're left wondering where their leadership is on this."
The frontline workers agree.
"We're concerned overall with the direction that this government," says Lester
from AIDS Committee of London. "It's about commitment to the issue."
Stop the cuts. www.IncreaseAIDSfunding.ca
By Marcus McCann, Capital Xtra |
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Canadian AIDS Care Nurses Voice Support for Harm Reduction
Harm reduction is part of professional and ethical nursing standards
April 22, 2008
Ottawa - Nurses caring for people with HIV/AIDS have a professional obligation
to promote the health and well-being of their patients, which includes supporting
strategies that reduce harm to patients dealing with addictions, says the
Canadian Association for Nurses in AIDS Care (CANAC).
At the close of CANAC's eighth annual conference, held April 21 - 22 in Ottawa,
the association is calling on municipal, provincial and federal governments
to immediately implement evidence-based harm reduction programs throughout
the country and to continue supporting those already operating.
"Nurses are concerned about the lack of support for essential harm reduction
programs in Canada," says CANAC President Greg Riehl. "Harm reduction has
been dropped from the current government's new 'Anti-drug Strategy', and
many vital programs are being threatened, including needle exchanges, the
safer crack kit program in Ottawa, and the supervised injection site (Insite)
in Vancouver, despite research showing that these programs work."
The City of Ottawa recently withdrew support for the city's safer crack kit
program and is now considering imposing a restrictive one-for-one needle
exchange policy.
"These actions represent a major step backwards," Riehl continues. "We need
maximum - not restricted - access to programs that prevent disease and suffering."
Insite is also under threat as the federal government must decide whether
to extend the exemption under which the facility legally operates. The current
exemption expires June 30, 2008.
Research on supervised injection sites show that these programs are effective,
says Liz Evans, a nurse and the director of the Portland Hotel Society in
Vancouver. The Portland Hotel Society operates Insite in partnership with
Vancouver Coastal Health.
"The federal government's own hand-picked expert advisory committee recently
confirmed that the facility prevents disease and death," explains Evans.
"We should stop talking about whether Insite should stay open and instead
start talking about expanding access to supervised injection sites throughout
Canada."
Nurses in Vancouver have also initiated a supervised injecting program at
the Dr. Peter Centre, a facility that operates a day program and residence
for adults living with HIV/AIDS. According to the Dr. Peter Centre's executive
director Maxine Davis, the decision to provide such a service was made after
consultation with the College of Registered Nurses of British Columbia (CRNBC).
"The College told us that, according to the requirements outlined in the
Standards for Nursing Practice in B.C., and the Canadian Nurses Association
Code of Ethics for Registered Nurses, there is a professional obligation
to provide clients with this evidence-based care and support so that they
can give themselves intravenous injections more safely," Davis explains.
Registered nurses are upholding professional and ethical standards of practice
by supporting harm reduction measures, adds Dr. Bernie Pauly, assistant professor
at the University of Victoria's School of Nursing.
"Harm reduction is a vital component of health care. This may be a controversial
matter to some Canadians, but it shouldn't be. At a basic level, it's simple:
this is a nursing practice issue," says Pauly. "Harm reduction is congruent
and consistent with established professional nursing values of safe, competent
and ethical care, health and well-being, dignity and social justice."
For interview requests or further information relating to the announcement,
please contact Stephen Burega, media relations, 604-506-3734, stephen.burega@karyo-edelman.com.
For onsite media relations, please contact Laura Espinoza, 647-883-3565,
laura.espinoza@edelman.com.
About the Canadian Association for Nurses in AIDS Care
The Canadian Association of Nurses in AIDS Care (CANAC) is a national professional
nursing organization committed to fostering excellence in HIV/AIDS nursing,
promoting the health, rights and dignity of persons affected by HIV/AIDS
and to preventing the spread of HIV infection.
About the Portland Hotel Society in Vancouver
The Portland Hotel Society (Vancouver, British Columbia) is a non-profit
organization that seeks to promote, develop and maintain supportive affordable
housing for adult individuals who are hard to house and at risk of homelessness
due to their physical and/or mental health, behaviour, substance dependencies,
and forensic history. The Portland Hotel Society operates Insite, Vancouver's
supervised injection site, in partnership with Vancouver Coastal Health.
About the Dr. Peter Centre
The Dr. Peter Centre is an HIV/AIDS day health program and 24-hour residence
in Vancouver, British Columbia. In addition to being HIV-positive, most Dr.
Peter Centre clients struggle with additional health issues, including mental
illness and addictions.
About the School of Nursing, University of Victoria
The University of Victoria School of Nursing is committed to providing leadership
in nursing education throughout British Columbia and Canada. Our approach
to teaching and learning is based on our respect for learners, and we see
teaching and learning as based on partnerships where learners' experiences
are valued. Throughout our programs we focus on the experiences of clients
as central to nursing practice.
www.marketwire.com |
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Blood Agencies' Ban on Gay Donors is Outdated and Unjustified
April 24, 2008
Giving blood is not a right.
The overriding responsibility of blood collection and distribution agencies
is not to ensure all Canadians are allowed to join in this altruistic act,
but to ensure the safety of blood and blood products for recipients.
To do so, agencies such as Canadian Blood Services and Héma-Québec must not
focus on concerns about rights. Instead they must discriminate - in the true
sense of the word.
Héma-Québec and CBS can and must exclude individuals (and sometimes entire
groups) from donating to protect the integrity of the blood supply.
At the same time, these agencies must strive to ensure there is an adequate
supply of blood, which saves the lives of thousands upon thousands of people
each year.
This is not an easy balancing act, particularly in a country such as Canada,
where the tainted blood tragedy has left us acutely sensitive to safety concerns.
There are, and always will be, restrictions on blood donors. Currently in
Canada, you can't donate blood if you are under the age of 17 or over the
age of 71, if you weigh less than 110 pounds (50 kilograms), if you have
a cold or the flu, or if you've had a tattoo or piercing in the past six
months.
There are also "indefinite deferrals" - or lifetime bans, if you prefer -
on members of certain groups. These include diabetics who use insulin and
people who have lived in African countries such as Cameroon, Congo and Nigeria,
where rates of HIV-AIDS are exceedingly high.
Because of fears of variant Creutzfeldt-Jakob disease (the human version
of mad cow), CBS excludes from blood donation anyone who has spent three
months or more in Britain or France between 1980 and 1996. (Héma-Québec puts
the British time limit at one month.)
Anyone who has used intravenous drugs or who has taken money for sex cannot
give blood. Also facing a lifetime ban from blood donation is any man who
has had sex with another man, even once, since 1977.
Some donor exclusions are justifiable and necessary. Some are perhaps justifiable
but are neither necessary nor useful. Regardless of what exclusions are in
place, there is the additional safeguard of testing. Blood is tested for
HIV-AIDS, hepatitis C, hepatitis B and syphilis, and these tests are quite
sensitive. Is there still, then, a sound basis of scientific evidence for
some of these deferrals?
When there is sufficient evidence, it's not enough to simply state the rules;
you need to explain them to the public.
And rules should be continually updated.
We owe it to ourselves to question these policies. For example, the ban on
donations by visitors to Britain and France seems arbitrary and unjustified.
It gives the illusion of doing something but, in effect, all it does is remove
a huge pool of donors without any appreciable safety benefit.
The same appears true of the lifetime ban on men who have had sex with men.
That approach was entirely appropriate when it was introduced in 1983. At
the time, the vast majority of those infected with HIV-AIDS were gay men
with multiple partners and tests were quite crude.
Today, the policy seems horribly outdated, based on current science. (Again,
rights are not the issue. The sole criterion is the balancing of risk and
benefits.)
It makes little sense to defer a heterosexual man who has had unprotected
sex with a female prostitute from blood donation for a single year, but to
impose a lifetime ban on a homosexual man who has been celibate for many
years.
Mark Wainberg and Norbert Gilmore of the McGill University AIDS Centre in
Montreal (and two of the world's leading researchers in the field) have been
lobbying to have the policy changed, and their arguments are convincing.
They note that the "prohibition against all gay men from being blood donors
forever fulfills no useful scientific purpose" and results in a tremendous
loss of potential donors.
A recent study estimated that lifting the lifetime ban would result in 136,000
more donations annually without compromising safety. The same study calculated
that there was a theoretical risk of one more contaminated unit of blood
every 18 years, a risk that was classified as "infinitesimally low."
To its credit, the CBS is not standing pat. It has commissioned a risk assessment,
a survey of donors and at least three academic studies of donations.
Most research looking at the risk of blood donations by gay men have focused
on the high-risk population, those with multiple partners. But few studies
have been done on those - the majority - in long-term, stable relationships.
There is no reason to believe their risk profile differs from most heterosexuals.
Continuing study cannot be an excuse for inaction in the face of overwhelming
evidence, as it was during the tainted blood scandal.
Australia has recently changed its rules. It now refuses blood donations
from gay men who have had "man-to-man sex" in the past 12 months. Italy,
for its part, asks donors if they have had a new sexual partner or unprotected
sex during the past year.
In our blood system, safety must be paramount. But as the science evolves,
so too must the rules.
Giving blood is the gift of life. It is a gift by civic-minded people who
operate largely on an honour system. We must discriminate for the purposes
of safety, but we must not thwart these heartfelt, life-saving donations
for no good reason.
By Andre Picard, www.globeandmail.com |
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AccolAIDS Winners
April 23, 2008
Several gay activists were honoured this month for their dedication to BC's
HIV/AIDS movement at the seventh annual AccolAIDS gala hosted by the BC Persons
with AIDS Society (BCPWA).
Ken Coolen was among the nine award recipients. Honored with the philanthropy
award, Coolen says providing community support is an intrinsic part of his
nature.
"People often say we should make a change, but I dive headfirst into projects.
I say, 'If it's not me, then who? If it's not now, when?'"
Coolen, who is also treasurer of the Vancouver Pride Society, says extensive
support from his family, community and colleagues has helped him reach his
goals.
The Community Based Research Centre (CBRC) was also acknowledged for its
innovative approach to research and gathering sexual health information in
the gay community.
The CBRC has been conducting the annual Sex Now Survey to gauge sexual health
and trends among gay and bisexual men since 2002. This year's findings indicate
a sharp increase in risky sexual behaviour in gay men 30 years and younger.
"We recognized in the late '90s that nobody was doing this type of research
and checking in with gay people to find out how they were doing," says CBRC
director Rick Marchand.
"There is a perception in the bureaucracy that we [gay men] have all the
support we need. [Heterosexuals] often don't think about the kind of supports
needed."
"Virtually all our friends are dead," adds CBRC research director Terry Trussler.
"We're [doing research] to prevent another crisis from happening."
By Shauna Lewis, Xtra West
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Grandmothers Helping Grandmothers
April 27, 2008
An estimated 13 million children have been orphaned by AIDS in sub-Saharan
Africa, and it’s the grandmothers of the country who have stepped up to care
for them.
After burying their own children, these women take in their grandchildren
and attempt to feed and clothe them while continuing to work.
In their 50s, 60s and even 70s, they become parents again. And not only to
their own family, but to their neighbour’s orphaned kids as well. Some grandmothers
take care of up to 20 children. One in particular has been known to care
for 28.
This is the information provided by the Stephen Lewis Foundation that South
Surrey resident Mary Harris heard at a workshop in Vancouver last fall. She
had been aware of Lewis’ humanitarian efforts towards people with HIV/AIDS
in Africa, after hearing him speak at a dinner a few years ago.
"I’ve always admired Stephen Lewis from the point of view that I trust him
and I trust his work," she said.
But it was the Vancouver workshop that had the biggest impact on Harris.
Two grandmothers from Africa had travelled to B.C. to speak at the workshop
about their plight.
Harris, a grandmother of three, was touched by the women’s spirit.
"I saw these very vibrant, energetic women," she said.
And she also saw a bit of herself. It was then and there that she decided
to do something to help.
The Stephen Lewis Foundation’s Grandmothers to Grandmothers campaign aims
to support grandmothers in Africa by fundraising and spreading awareness.
Since the launch in 2006, nearly 200 groups of Canadian grandmothers have
assembled, raising more than $2 million for the cause.
With no such group in the White Rock/South Surrey area, Harris brought her
attention back home. She contacted the foundation and received the materials
to start her own chapter of grandmothers.
And she named the group The Oneness Gogos – the word gogo meaning ‘grandmother’
in the Zulu language, and ‘oneness’ reflecting how everyone is equal.
The Oneness Gogos, like many other grandmother groups, will have three main
focuses – fundraising, advocacy and education. Three committees will be formed
to head up each task, and the group will work together to meet the goals.
"Anyone can be a part of the group," Harris said.
Money raised will go to the Stephen Lewis Foundation, which directs the funds
to community-level organizations in 15 sub-Saharan African countries that
provide grandmothers with food, housing grants, school fees for their grandchildren
and grief counselling. It’s a cause Harris feels strongly about. Even after
travelling to Africa about two years ago, she can’t fathom the challenges
some African grandmothers are faced with every day.
"(I) just can’t imagine anything like that," she said.
Harris said it’s important to support the campaign, because without the grandmothers
looking after orphans, there wouldn’t be anybody.
"There would be no food for the children – they wouldn’t be looked after."
For more information about The Oneness Gogos, call Lucinda Lyall at 604-541-2206.
http://www.bclocalnews.com |
International News
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PAWS Protects Pets of Those Who Need Them Most
April 19, 2008
San Francisco - Imagine you are diagnosed with a disabling illness such as
HIV/AIDS or cancer.
You live alone in San Francisco on a fixed income of $900 a month, and struggle
each day to pay for food, housing and medicine. Imagine you have no companionship,
save your beloved dog or cat. And imagine, on some days, you face a grueling
decision: Who will get to eat, you or your pet?
In 1986, that was the heartrending discovery San Francisco AIDS Foundation
volunteers made while providing food to AIDS patients. They learned that
their clients, for whom nutrition plays an especially vital role in their
well-being, were giving their rations to their pets instead of using it for
themselves. As a remedy, volunteers began stocking pet food, but demand was
so great that in 1987, a new nonprofit organization was created.
Today, PAWS (Pets Are Wonderful Support) is a well-known and valued service
that permits lower-income San Francisco residents to keep their pets by providing
emotional and physical support through a number of services. These include
a pet food bank, subsidized veterinary care, in-home animal care and counseling/advocacy
services for animal and housing issues.
"In the late 1980s there was a lot of misinformation about HIV/AIDS, and
many patients lost the support of their family and friends," said John Lipp,
president of PAWS.
"All they had left was the unconditional love of their pets. PAWS began as
a grassroots movement to help HIV/AIDS patients keep their animal companions.
The community rolled up their sleeves and said, 'We'll take care of our own.'
"
However, the importance of animal companionship is not limited to the HIV/AIDS
community. And recognizing that, five years ago PAWS expanded its scope of
services to include people living with mental health problems or life-threatening
illnesses. In 2007, they added low-income seniors.
"Too often, seniors live isolated lives and don't have a lot of support,"
Lipp said. "Pets are a lifeline for them."
Indeed, he has seen the PAWS client base increase 35 percent over the past
two years. "We currently have about 650 active clients, and over half of
those receive monthly pet food and supplies," he said. "About 25 percent
of our clients are homebound, and in those cases, we deliver to them."
Lipp is referring to the 360 volunteers who are assigned to help clients
walk their dogs, provide foster care for pets when there is an emergency,
and offer rides to veterinarian and grooming appointments. Volunteers also
perform in-home animal care such as changing cat boxes, since bacteria-laden
feces can be hazardous to someone with a compromised immune system.
These deceptively simple services are a godsend to people who might have
otherwise faced relinquishing their pets because of health or finances. One
such grateful recipient is a minister who goes by the name Phoenix. When
the 48-year-old Philadelphia transplant suffered a heart attack, his doctor
recommended that he get a dog to encourage exercise.
Phoenix, who is also HIV-positive, worried about paying veterinarian bills
on his fixed income. But two years ago, those concerns vanished when he was
strolling through San Francisco's Animal Care and Control kennel and fell
in love with Dusty, a spunky 1-year-old terrier mix.
"I took him home, and that was one of the best things I've ever done," said
Phoenix, who has since appeared on the Travel Channel as a San Francisco
tour guide, with Dusty hamming it up by his side. "When I think of what this
dog means to me, I get teary-eyed."
He recalls that when Dusty was diagnosed with kennel cough and later ate
something that made him ill, both times he was nursed back to health thanks
to the veterinary support offered by PAWS. "If it weren't for them, I wouldn't
have been able to get a dog."
As any pet owner knows, a trip to the veterinarian's office can often result
in an emptied wallet. "That's why every client is given up to $200 annually
for vet care," Lipp said. "We also offer free annual wellness exams in partnership
with Pets Unlimited, in addition to a critical-care fund for emergencies."
PAWS serves eligible San Francisco residents only. However, as the first
of its kind, it has mentored similar organizations nationwide. Lipp said
PAWS hopes one day to have a permanent facility with on-site grooming, kennel
space for animals whose guardians need emergency hospitalization or treatment,
and increased space for the food bank because "the more we can take in, the
more we can give out."
Phoenix said that after his heart attack, he was fearful of doing too much,
a common concern. This fear led to him staying home and becoming a TV-watching
recluse.
"Besides losing several friends to HIV, the realization of having to retire
because of my heart attack knocked the wind out of my sails," he said. "Until
I got Dusty and rejoined the human race, I didn't realize the toll my illnesses
had taken on me. Dusty ensures that I have to be responsible because how
can I take good care of him if I don't take good care of me?"
And that's what PAWS is all about.
To learn more about PAWS go to www.pawssf.org
By Eileen Mitchell, San Francisco Chronicle |
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HIV-Positive Men Find a True Home and Friends At Jo-Ray House
One of the disease's most crippling effects is social isolation, says
a resident aided by the home's founder, Ida Byther-Smith
April 20, 2008
Chicago - After years of living a street life, Woody Easley has finally found
a home, and a new life, at a residential facility in Chicago's Roseland neighborhood.
Easley, 60, was asked to leave another residential house in Chicago when
he disclosed he was HIV positive. Now, he is one of six residents of Jo-Ray
House, a home for HIV-positive men on the South Side.
The men come from different backgrounds and have varied pasts. Some have
held promising careers, some have struggled with addiction, others have had
run-ins with the law.
But they all have one thing in common: They found Ida Byther-Smith, the founder
of Jo-Ray House, or she found them.
Byther-Smith cashed in her life savings and started Jo-Ray House in 2003
after meeting a man who contracted HIV through prison rape. His family threw
him and everything he touched out when he told them he was HIV positive.
But it is her own experience that allows Byther-Smith to identify with the
men on a personal level.
"[HIV] is a pot. It doesn't matter how you got in, whether you jumped in
or got pushed," she said. "All that matters is we are all in the same pot."
Byther-Smith, 58, was diagnosed with HIV in 1991 and learned soon after that
her husband had had affairs with men and women.
Instead of focusing on anger and turning her back on her husband, Byther-Smith
took care of him until he died eight years later. People who know her story
are sometimes surprised that she decided to take in men with HIV, she said.
But she believes in the end that she also is helping women.
"If I can reach one man with HIV and help him get past his anger, maybe I
can save one woman from being infected like me," Byther-Smith said.
And as long as she has space, the men are welcome at Jo-Ray House, which
is named after relatives, she said.
"Ida's door is always open," said John Brady, 42, one of Jo-Ray's original
boarders, who is in his fourth residency at the house.
"She loved me until I learned how to love myself," said Brady, now a volunteer
group leader for Haymarket Center, an alcohol and drug treatment program
on the West Side.
There are house rules, but the men are free to come and go as they please.
They each pay $360 a month for rent, though it's not a requirement. Byther-Smith
doesn't turn anyone away because of income, she said.
She also has qualified for grants from the AIDS Foundation of Chicago, which
reports that one of the biggest obstacles for people with HIV/AIDS is finding
adequate housing.
"The housing issue is becoming a public health issue," said Arturo Bendixen,
housing director for the AIDS Foundation of Chicago. Bendixen said 50 percent
to 60 percent of people living with HIV/AIDS reported being homeless or experiencing
housing instability.
"It is very difficult to find a place to store your medicine and to refrigerate
it when you're homeless," said Bendixen, who added that the homeless with
HIV/AIDS are five times more likely to die. "Some HIV/AIDS regimens require
taking [medication] different times of the day. People on the streets or
in a shelter don't have a lot of control over their regimens."
The men at Jo-Ray House speak openly about being HIV positive.
In an upstairs bedroom, Shelly Crum, 37, and Ed Phelps, 52, watch TV as they
recount being diagnosed with HIV.
"I was just 24 years old," said Crum, a former postal worker. "I was trying
to purchase life insurance and got a call that I needed to see my doctor."
Crum said he contracted the virus from a girlfriend who has since died.
Phelps, a native New Yorker, said he tested HIV positive three years ago
on Valentine's Day.
As he sat on a twin-size bed with his legs crossed, he talked about survivor's
guilt and his 14-year battle with addiction. His partner died of AIDS soon
after finding out he was infected, Phelps said.
The hardest obstacle he had to overcome was social isolation, said Phelps,
who was once married.
"I was angry with the universe," he said. "The real killer is not the possibility
of a physical death, it's the social death."
Byther-Smith hopes the stigma of HIV vanishes when you walk through the doors
of Jo-Ray House. But keeping the doors open has been a struggle.
Byther-Smith said her faith has kept her going. "God knew that there was
going to be a little black lady in Chicago that would contract HIV from her
husband. That was my destiny," Byther-Smith said.
"But my choice was what I was going to do with [HIV]."
By Deanese Williams-Harris, www.tribune.com
|
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Tainted Blood Inquiry Announced
April 23, 2008
Details of a Scottish public inquiry into the infection of NHS patients with
hepatitis C and HIV through blood products have been announced.
Health Secretary Nicola Sturgeon said previous government-led inquires into
the issue lacked independence.
Hundreds of people in Scotland, including haemophiliacs, were given the tainted
blood in the 70s and 80s.
The previous Holyrood government resisted calls from campaigners for a public
inquiry into the issue.
A total of £3m has been earmarked for the independent inquiry, which will
be chaired by the former judge and sheriff, Lady Cosgrove and is expected
to start hearing evidence towards the end of the year.
It will also specifically look into the deaths of two infected patients,
72-year-old Eileen O'Hara and Rev David Black, 66, in 2003.
In a separate case, judge Lord Mackay quashed a previous decision not to
hold fatal accident inquiries into the cases, and ruled their human rights
were breached.
Ms Sturgeon told the Scottish Parliament: "The transmission of hepatitis
C and HIV through blood and blood products is a tragedy that has blighted
the lives of many people in Scotland.
"That is why we are committed to a thorough inquiry to get to the bottom
of this.
"We owe an explanation to patients and the public of what took place. We
are determined to provide that."
The Scots investigation is expected to look into where NHS blood and blood
products previously came from, whether they were effectively screened and
whether heat treatment could have been introduced earlier.
It will also probe the practices of the blood transfusion service at the
time.
Ms Sturgeon said the events took place at a time when evidence about blood-borne
viral infections was more limited - but said, even then, there were indications
that tainted blood supplies existed.
"There is no doubt that the people affected and their families deserve nothing
less than answers to these questions," she told MSPs
"If they are to achieve any sort of closure, we need to get to the bottom
of what has been one of the most tragic episodes in NHS Scotland in the provision
of treatment with blood and blood products."
One patient, haemophiliac Robert Mackie, who was diagnosed with hepatitis
C and HIV in the early 80s, said an inquiry would provide some answers but
would never give him back the life which he said was stolen from him.
He told BBC Scotland: "The day I was told I was infected, my life ended as
far as I was concerned. Life as I knew it was over.
"None of us knew of these risks or were even told of these risks."
The Conservatives and Liberal Democrats welcomed the inquiry, as did Labour
- although the party questioned what extra benefit it could bring, given
a similar investigation was currently under way in England.
http://news.bbc.co.uk |
|
Iran Offers Addicts Condoms, Syringes from Vending Machines
April 16, 2008
Tehran - Iran is installing vending machines in Tehran to sell cheap condoms
and syringes to drug addicts to prevent the spread of AIDS and hepatitis,
an official said on Wednesday.
"Five of these machines which have been made will be installed in five of
Tehran city's welfare shelters for addicts," the deputy head of Iran's anti-narcotics
organization, Mohammad Reza Jahani, said.
"Condoms, syringes, bandages and plasters will be easily accessible just
by inserting a coin. This protects addicts from acquiring AIDS and hepatitis,"
he added, according to the semi-official Fars news agency.
He said that a single 500 rial (five cents) coin is required to purchase
the items.
"The machines will be used for a three month trial period and if the scheme
is successful then we will upgrade them and increase their distribution to
other shelters," he added.
Iranian officials admit the country has a serious drug abuse problem. They
normally estimate the number of regular drug users at two million in a country
with a population of more than 71 million
Iran is situated along one of the main trafficking routes for cannabis, heroin,
opium and morphine produced in Afghanistan, and designer drugs have also
found their way into the Iranian market in recent years.
Out of 2,500 tonnes of narcotics that enter Iran from neighbouring Afghanistan
annually, some 700 tonnes are consumed in the country, officials say.
Condoms are freely available in Iranian pharmacies.
The Islamic republic in the 1990s started actively promoting contraception
as it encouraged families to have just two children to prevent the country's
population growth increasing further.
Iran has tried to change its approach to drug addicts by treating users as
"people who need help" rather than throwing them into already overcrowded
jails.
AFP |
| Peace Corps Fires Man with HIV
April 22, 2008
New York City - The American Civil Liberties Union has sent a letter to the
Peace Corps demanding that it change its policy of barring people with HIV
from serving as volunteers.
The letter was sent on behalf of a Denver, Colorado volunteer who was sent
home from his post in the Ukraine and terminated after he tested positive.
"I joined the Peace Corps because I wanted to learn more about the world
and help people," said Jeremiah Johnson.
"It was hard enough to learn that I had contracted HIV, but to then be shipped
home and told I was unworthy of finishing my service was incredibly humiliating."
Johnson, now 25, began his tour as a Peace Corps volunteer in December 2006.
He tested negative for HIV prior to beginning his service.
For nearly thirteen months, he was the sole volunteer in Rozdilna, Ukraine,
where he taught English to middle and high school students.
In January 2008, Johnson, who was in Kiev to attend a Russian language program
with other volunteers, received a midservice medical examination and opted
to take an HIV test.
After the results confirmed that he was positive for the disease, he was
immediately told that he could no longer work in the country because of a
Ukrainian law barring people with HIV from working in the country. He was
also told he would not be able to finish his service elsewhere.
Although he had no health problems, he was only allowed to return to Rozdilna
for two days to pack his bags and say goodbye to the people he had met during
his tour, the ACLU said in a statement.
He was forced to abandon projects that he had been developing to help the
community. Johnson was then sent to Washington, D.C., for an end-of-service
medical exam.
The ACLU said that while in DC, he again asked Peace Corps officials to explain
why he was being terminated and asked if he could continue his service elsewhere,
but these requests were denied. Instead, he was given an automatic medical
termination, stating HIV as the reason for his termination.
The ACLU’s demand letter charges that it is illegal under the Rehabilitation
Act for the Peace Corps to discriminate against Johnson because he has HIV.
The letter cites a recent federal appeals court decision finding that it
is illegal for the Foreign Service to bar people with HIV from serving.
In that case, the Foreign Service, which also sends workers around the globe,
had argued that it was justified in barring people with HIV from service
in order to protect the health of people with HIV who would be stationed
in areas with limited access to medical treatment. The court rejected that
rationale.
"There is not a single justifiable reason for the Peace Corp to bar people
with HIV from serving as volunteers," said Rebecca Shore, an attorney with
the ACLU’s AIDS Project.
"Jeremiah was, and continues to be, in good health, fully capable of performing
his responsibilities. It is especially disappointing that an agent of our
government would have an illegal and discriminatory policy barring people
with HIV from trying to make the world better."
The ACLU’s letter demands that the Peace Corps change its policy or confirm
that it does not have a policy of automatically excluding all people with
HIV. According to the ACLU, the Peace Corps must consider on an individualized
basis whether an applicant with HIV can volunteer, including making every
effort to place those who are able to serve in a country that doesn’t bar
people with HIV from working in the country.
"It was hard being sent home the way I was." Johnson said. "I had no time
to plan for my return."
"I was forced to have a lot of conversations I wasn’t really ready to have.
I had no money, no job and no place to live. Fortunately, my family welcomed
me back with open arms and helped me get back on my feet," said Johnson.
"But one thing I’ve come to realize is that having HIV won’t stop me from
realizing my dreams of helping others. I hope by bringing attention to what
happened to me, the Peace Corp will realize that too."
http://www.365gay.com
|
Studies & Treatment News
|
Genetic Immunity Announces Data Related to the DermaVir Nanomedicine Patch
in the Journal of Immunology
April 21, 2008
Data Supports Use of HIV-specific T cell Precursors with High Proliferative
Capacity (PHPC) Marker to Predict Reduction of Viral Load
Mclean, Va., And Budapest, Hungary - Genetic Immunity(R), a US/Hungarian
clinical-stage company focused on patented nanomedicines for immune amplification,
announced today that the Journal of Immunology published findings on a key
biomarker currently being used in clinical studies of its lead HIV/AIDS nanomedicine
candidate, the DermaVir Patch. The paper, entitled "HIV-1-Specific T-Cell
Correlate with Low Viremia and High CD4 Counts in Untreated Individuals,"
highlights data from a study conducted by Sandra Calarota, Ph.D., of the
Research Institute for Genetic and Human Therapy (RIGHT).
In Dr. Calarota's study of 32 HIV-1 infected individuals, high immunological
responses measured by a novel assay of T cell Precursors with High Proliferative
Capacity (PHPC assay) better correlated with viral suppression and positive
immunologic outcomes, than did the traditional ELISPOT assay.
These data further validate and support results from a clinical study of
Genetic Immunity's DermaVir Patch presented in February 2008 at the 15th
Annual Conference on Retroviruses and Opportunistic Infections (CROI). The
study demonstrated that the DermaVir Patch induced a significant increase
of PHPC counts in all 9 HIV-1-infected participants, suggesting that the
DermaVir Patch may promote a targeted amplification of the immune system
capable of reducing the amount of circulating HIV virus.
Dr. Franco Lori, the lead author of the study said, "The correlation between
high PHPC counts and low viral load in HIV-infected subjects suggests that
the presence of a greater number of T-cells that have retained their ability
to expand and function normally may be a better predictor of patient outcomes.
This new PHPC assay may also be a valuable tool in the development and testing
of urgently needed nanomedicines, immune therapies and prophylactic vaccines
for a number of diseases in addition to HIV/AIDS."
Julianna Lisziewicz, Ph.D., Co-Founder and CEO of Genetic Immunity, said,
"The design and testing of the DermaVir Patch has long focused on PHPCs as
a marker. We see these results as validation that our approach has been scientifically
sound.
About Genetic Immunity(R)
Genetic Immunity is a US/Hungarian development stage biopharmaceutical company
establishing leadership in Nanomedicines for immunity amplification. next-generation
biopharmaceuticals. Nanomedicine, an offshoot of nanotechnology, refers to
highly specific medical intervention at the molecular scale for curing disease
or repairing damaged tissues, such as bone, muscle, or nerve. The Company
is leveraging its proprietary immune amplification platform technology, Genetic
Immunity aims to create new markets for infectious diseases, cancer and allergies
through the discovery, development and commercialization of topically administered
nanomedicines. These indications represent a significant unmet medical need
and the potential for alternative treatment approaches. Genetic Immunity's
founders discovered the lead product nanomedicine candidate, the DermaVir
Patch for the treatment of HIV/AIDS. The DermaVir Patch is in Phase II clinical
development and could be the first nanomedicine immune therapy approved for
HIV-infected individuals. DermaVir Patch has demonstrated excellent safety,
immunogenicity and antiviral efficacy in preclinical studies. Phase I/II
trials to date have confirmed safety and tolerability and indicate the induction
of long-lasting HIV-specific T cells.
About the Nanomedicine Technology Platform
Genetic Immunity's immune amplification platform technology is used to develop
nanomedicines comprised of two principal components: NanoComp and DermaPrep.
NanoComp is a patented nanoformulation technology that includes disease-specific
plasmid DNA encoded antigens. DermaPrep is the topical administration device
that delivers NanoComp into a patient's lymph node dendritic cells to induce
T cell mediated immune responses that can alleviate a broad spectrum of diseases.
These two components together make up the DermaVir Patch. The plasmid DNA
within DermaVir Patch's NanoComp nanoparticles is specific to HIV and topically
delivered via DermaPrep to amplify the immune system to kill only HIV-infected
cells.
Contacts: The Ruth Group Investors Media Sara Ephraim Janine McCargo +1-646-536-7002
+1-646-536-7033 sephraim@theruthgroup.com jmccargo@theruthgroup.com
Genetic Immunity
PR Newswire |
|
Scientists Test Device to Track Medication Adherence in Patients with HIV/AIDS
April 21, 2008
Gainesville, Florida - Most of us have missed a dose of antibiotic or forgotten
to take a daily vitamin. But when the stakes are higher — as they are for
people with HIV/AIDS — a skipped pill could mean the difference between health
and hazard for the entire population.
Now, a breath monitoring device developed by scientists at the University
of Florida and Xhale Inc. could help prevent the emergence of drug-resistant
strains of HIV by monitoring medication adherence in high-risk individuals.
"For HIV, it’s been shown that if you don’t take a very high percentage of
your medication, you may as well not take medication at all," said Richard
Melker, M.D., a professor of anesthesiology at the UF College of Medicine
and chief technology officer for Xhale.
Patients who take some but not all of their medication increase the likelihood
the virus will mutate into a deadlier, drug-resistant form. Experts have
tried literally hundreds, if not thousands, of ways to monitor drug adherence,
ranging from daily log books to blister packs that record the time each pill
is dispensed. Despite the money, time and effort devoted to these methods,
Melker said only one works well: directly observed therapy, or DOT.
"If you have a disease that is deemed to be a public health risk, authorities
can put you into a program where you have to come to the clinic every day
and be observed putting the pill into your mouth and swallowing it," Melker
said.
But that process is inconvenient for patients, as well as for clinic personnel
who have to track them down when they fail to show up. A breath-monitoring
device developed by UF scientists and Xhale could change that, allowing patients
to participate in a type of virtual DOT from home.
"The machine sits in your home and when it’s time for you to take your medication,
it makes a beeping noise. If you don’t hit a button after about five minutes,
it’s going to beep louder and louder until you come," Melker said. "If you
don’t come after a certain amount of time, the machine can call the clinical
trial coordinator and indicate that subject or patient didn’t take the medication
as prescribed."
The device, which is slightly smaller than a shoebox, records the results
of each breath test, allowing patients to bring a memory card or USB key
to the clinic once a month and receive a printout of their results. Eventually,
the researchers hope to reduce the size of their detection device to fit
inside a cell phone. But for now, they’re satisfied that the technology works.
"The doctor can see how often you took it and exactly what time. If it made
the patient really sick or dizzy and they didn’t take it, they can find out
why," Melker said. "It’s not just a question of did I or didn’t I take it,
but when you took it or why you didn’t take it."
The researchers developed the adherence monitor by incorporating minute amounts
of an alcohol into a gel capsule. The additive, called 2-butanol, is one
of many GRAS — Generally Recognized as Safe — compounds approved by the Food
and Drug Administration for use in foods.
"We wanted (patients) to swallow a chemical and have it transform into something
else that’s easy to monitor," said Matthew Booth, Ph.D., an assistant professor
of anesthesiology at the UF College of Medicine and an investigator in the
study. "When it hits the stomach lining and liver, an enzyme converts the
alcohol to a gas that can be measured in the breath."
To determine how well the byproduct could be detected, six healthy volunteers
swallowed empty pills in which the capsules contained trace amounts of 2-butanol.
After five to 10 minutes, the scientists could measure the volatile byproduct
in the volunteers’ breath using a small detector. The scientists say their
device could also be used to monitor medication adherence in patients with
other communicable diseases, such as tuberculosis.
"It is encouraging that the biological and chemical elements of the adherence
system work as predicted. We were able to conclusively show who swallowed
the capsules containing the 2-butanol. With further optimization, we are
optimistic the device will perform very well," said Donn Dennis, M.D., the
Joachim S. Gravenstein professor of anesthesiology at the UF College of Medicine
and an investigator in the study.
The researchers say the device may prove equally helpful for monitoring adherence
in clinical trials.
"If you enroll HIV/AIDS patients in a clinical trial and they don’t take
the medication, then you may not get adequate proof that the drug is effective,"
Melker said. "It might be effective, but some of the patients aren’t taking
it."
Phase 2 trials are often conducted in the community, rather than at research
institutions, making it difficult for researchers to monitor adherence. As
a result, many trials enroll a larger group of subjects than needed, in hopes
they’ll obtain enough data to determine the safety and efficacy of the medication.
"If we had a good way of doing DOT that’s realistic, instead of having someone
come to your house or you going to clinic every day of your life, then we
would know whether these people stopped taking their medication and why.
Right now, nobody knows any of that." Melker said. "The implications of being
able to understand what normal human behavior is in a clinical trial and,
of course, in the real world, are huge."
By Ann Griswold, http://www.eurekalert.org |
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‘No Benefit' From Diabetes Self-Tests
April 23, 2008
Two studies have cast doubt on the impact of encouraging people with type
2 diabetes to monitor their own blood sugar levels.
The findings suggest the move may have little effect on improving care and
also be a waste of NHS resources.
Published in the British Medical Journal, one study indicated that patients
who self-test are more likely to end up depressed than in better health while
another claimed that self-testing costs £90 extra per patient per year and
may lead to a worse quality of life.
While monitoring blood sugar levels means patients, such as those with type
1 diabetes who need to take insulin, can control their disease, there has
been a move in recent years to encourage self-testing for those patients
who have type 2 diabetes.
A trial of 180 people who had been newly referred to a hospital diabetes
clinic in Northern Ireland found self-monitoring did not improve blood glucose
control compared with normal care.
Study leader Dr Maurice O’Kane said: "What we can say is if people do not
want to monitor there’s no evidence their care will be inferior."
University of Oxford researchers looked at the cost-effectiveness of self-monitoring
in type 2 diabetes.
Study leader Dr Judit Simon said routine self-monitoring did not prove to
be cost-effective and there was a negative effect on the quality of life
for some people.
Diabetes UK said decisions on self-monitoring had to be made on an individual
basis with patients being educated on what to do with the results.
http://www.hc2d.co.uk |
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Patients May Not Need Tests While On AIDS Drugs
April 25 2008
London - Patients with HIV who are not monitored with the expensive laboratory
tests commonly used in rich countries may survive just as long as those who
do get the tests, a new study says.
In a paper published in The Lancet medical journal Friday, experts found
only a slight difference between the survival rates of HIV patients on AIDS
drugs who were monitored with laboratory tests and those who were not. Lab
tests can be an early indication of problems in HIV patients that are not
yet obvious.
The research was based on computer modelling, and while the results must
be verified, they could influence how HIV patients across Africa and Asia
are treated.
As drugs to combat AIDS have been distributed in developing countries, some
doctors worry that without lab monitoring, patients will either die earlier
or develop drug resistance faster. But based on the evidence to date, that
has not happened.
"We often get stuck in letting the perfect be the enemy of the good," said
Jennifer Kates, an HIV expert at the Kaiser Family Foundation in Washington.
She was not connected to the study.
"Waiting for the perfect lab infrastructure to be ready before rolling out
antiretroviral therapy (AIDS drugs) means that millions of people will die,"
Kates said. "This study says we shouldn't wait."
Andrew Phillips and colleagues from the Royal Free and University College
Medical School in London used a computer model that simulated patient details
based on HIV progression in real patients. They then projected the patients'
survival for up to 20 years. Data from real patients are not yet available.
Phillips and his colleagues essentially found that 83 per cent of patients
who were monitored with lab tests survived five years, compared with 82 per
cent for those who went without the tests. Over two decades, 67 per cent
of those who got lab tests survived versus 64 per cent for those who did
not.
The difference is negligible - and contradicts long-held beliefs that AIDS
drugs must be accompanied by regular laboratory monitoring to benefit patients.
Phillips developed the original computer model with funding from Pfizer Inc.,
makers of many of the drugs used to fight HIV and AIDS.
Some experts worry that because people who are not monitored with lab tests
stay longer on drugs that do not work, they could be spreading drug-resistant
HIV.
Nathan Ford, head of Medecins Sans Frontieres' medical unit in South Africa,
said there are no signs that drug resistance is developing more quickly in
Africa than elsewhere. Ford was not involved in the study.
AP, www.ctv.ca |
|
Elite HIV Patients Offer Vaccine Clue
Montreal scientists uncover how infected patients stay AIDS-free
April 25, 2008
A major chink in the armour of the HIV virus has been opened up by a largely
Canadian team of researchers who appear to have discovered - and learned
how to counter - the key chain of events that leads to immunodeficiency in
most people infected with the disease.
The researchers, led by Dr Rafick-Pierre Sékaly of the University of Montreal
and Dr Elias Haddad of McGill University, identified the vital transcription
factor, named FOXO3a, by examining blood from "elite controllers." These
are the small class of HIV-infected patients who remain AIDS-free even without
antiretroviral treatment because their immune system never fails. Their results
are published in the March issue of Nature Medicine.
Elitist Attitude
About one in 300 HIV-infected people is an elite controller, but most are
never identified because they never develop any symptoms and never get an
HIV test. They also don't pass the disease on to others, because their viral
load is negligible.
"Given their perfect resistance to HIV infection, elite controllers represent
the ideal study group to examine how proteins are responsible for the maintenance
of an immune system with good anti-viral memory," Dr Haddad told the media.
"This is the first study to examine, in people rather than animals, what
shields the body's immune system from infection and to pinpoint the fundamental
role of FOXO3a in defending the body."
A large part of the elite controllers' secret is now revealed. We already
knew that their viral load remains low because their central memory CD4+
T cells don't die off as they do in the majority of infected people. In grossly
simplified form, what the new research uncovers is that these cells die in
most people because each time the immune cell's receptors are triggered,
FOXO3a transcription factor is driven into the nucleus, where it triggers
production of proteins associated with programmed cell death, or apoptosis.
Culture Club
When T cells from elite controllers and from aviremic HIV patients successfully
treated with antiviral therapy were studied in culture with repeated receptor
triggering, they proliferated equally, but those from the elite controllers
survived far longer, with a half-life of 13.1 days compared to just 4.3 days
for the successfully treated patients. By 12 days the elite controller cultures
had 2.5 times as many central memory CD4+ T cells left as did cultures drawn
from successfully treated patients. By day 19, almost all of the latter group's
cells were dead, but the elite controllers' cells were still proliferating
merrily.
In fact the elite controllers' central memory CD4+ T cells were considerably
more robust than those of HIV-negative blood donors whose blood was also
studied as a control. The researchers had only to add this piece of the puzzle
to a vital finding they made last year - that FOXO3a is the key pathway in
T cell apoptosis - to come up with a pretty good hypothesis on what is preventing
T cells from disappearing in these rare elite controllers. Namely, that their
FOXO3a pathway doesn't work as it does in most people.
Better yet, it gave them an idea what to do about it, and this is the part
that really grabbed the world's attention and set this work apart. Taking
the cells of their successfully treated HIV patients, they infected them
with lentiviruses carrying a "dominant-negative" form of the transcription
factor, FOXO3a Nt, which can travel to the nucleus and compete with the transcriptionally
active FOXO3a for binding to DNA.
The cells from the successfully treated HIV+ subjects, when infected with
this virus, showed far lower levels of the apoptotic factors that had previously
been shutting them down. Sure enough, in vitro, their lifespan dramatically
increased, so that these cultures, like the elite controllers' cultures,
still had plenty of T cells left at 26 days, and almost all of those still
alive were the ones that had been infected with the mutant-carrying lentivirus.
In effect, this in-vitro culture had been vaccinated against AIDS.
Long and Winding Road
Of course it's a long way from this kind of study to a real human treatment.
The lentivirus, by day 12, had only infected about a quarter of the T cells
in each culture, and the others went on to die as usual. But neither is this
anything like the typical cell biology study, which researchers claim "may
lead" to future treatments. These researches have suggested and tested a
specific approach that has huge clinical promise, both as a vaccine and as
a treatment.
It would be unlikely to provide sterilizing immunity, since a vaccine based
on this approach does no direct harm to HIV. But HIV vaccine research has
shifted focus anyway in recent years from the fruitless search for sterilizing
immunity to an approach that seeks to break secondary transmission after
infection by keeping the viral count low.
The FOXO3a pathway is a completely new avenue of attack, and one that may
have a role to play far beyond HIV/AIDS. "The discovery of FOXO3a will enable
scientists to develop appropriate therapies for other viral diseases that
weaken the immune system," said Dr Sékaly, adding that he foresaw potential
uses in cancer, rheumatoid arthritis, hepatitis C, and transplant rejection.
By Owen Dyer, http://www.nationalreviewofmedicine.com |
Interview
|
Interview: Stephen Lewis
Africa: Activist Praises Europe, Slams U.S. on AIDS
24 April 2008
Stephen Lewis is a renowned and vigorously outspoken Canadian diplomat who
has worked extensively to reduce the impact of HIV/AIDS in Africa and to
advocate for those living with the disease.
Formerly the special envoy for HIV/AIDS in Africa for United Nations Secretary-General
Kofi Annan, he is now chairman of the board of the Canada-based Stephen Lewis
Foundation, which endeavors to ease the pain of HIV/AIDS in Africa by funding
grassroots projects. Lewis is also co-director of AIDS-Free World, a new
international AIDS advocacy organization based in the United States.
In a wide-ranging interview with AllAfrica's Cindy Shiner, Lewis discussed
current efforts to fight HIV/AIDS and how Africans are coping. This is the
second of a three-part series.
Do you feel the international community is doing enough now to address HIV/AIDS
in Africa?
No, they're not. It's much better than it was three to five years ago but
the international community still is not galvanized enough in sufficient
support of Africa to respond to the pandemic. If it were we would long ago
have supplied much more help in the replenishment of the lost human resources…
[and] in the repair of health infrastructures.
We would have years ago put in place the prevention of transmission from
mother to child [of the virus] during the birthing process. We would have
invested much more in the orphaned children. We still have millions of people
in need of treatment. It's unlikely we will reach the goal of universal access
to treatment by 2010.
What is your view of the President's Emergency Plan for AIDS Relief (Pepfar),
the 50-billion-dollar initiative of the Bush administration in the United
States?
Everybody is so shocked at getting a sizeable amount of money that they forget
that there are tremendous flaws in Pepfar, most of which are destructive
towards women. The amount of money is not sufficient and they should be clamoring
for much more instead of this endless acting as a cheerleader for the administration.
Do you have some specific examples of ways in which you say it falls short?
Pepfar still insists that up to 50 percent of the preventative monies be
spent on abstinence and fidelity when abstinence clearly isn't a choice for
so many women, not only young women who are already sexually active, but
women in marriage. Fidelity isn't the problem of the women in marriage; it's
the problem of the men in the marriage … It's an outrageous continuation
of an ideological weapon wielded by an administration which is reactionary
and out of touch with the real world.
Then there is the prostitution gag rule, where you can't work with sex workers
when in fact they are a high-risk group with whom organizations must work.
That's another attack on women. And then there's the fact that you can't
do reproductive and sexual health in conjunction with work on HIV/AIDS when
obviously the two are inexorably linked. That's another attack on women.
Here you have a piece of legislation where the money is inadequate and the
flaws are all rooted in misogyny… in attacks on women. People are applauding
it as if it's some sort of contemporary Marshall Plan. That's crazy and it
should be seen for what it is – both inadequate and irresponsible in many
respects.
What do you think should be done?
People should demand more – much more. No one denies that when you pump several
billion dollars into a response it will mean something. Of course it will;
millions of people will be treated. That's terribly important.
But that's what we deserve to expect from the United States. You don't kneel
down before a country because it's doing… something that the world has a
right to receive. The American administration is so discredited, George Bush
is such a lamentable president, that when anything of a positive kind happens
people are prostrate at the unlikelihood of it and they shouldn't be.
The defining reality is that the United States is spending somewhere between
12.5 and 15 billion dollars a month on the war in Iraq and people are celebrating
the fact that [it] will spend 10 billion dollars a year to fight the three
worst communicable diseases in the world, which collectively have taken between
30 and 50 million lives. In the case of AIDS alone there are 33 million people
living with the virus.
So the distortion of priorities for conflict rather than human need is grotesque.
People should not be cheering the United States for giving a pittance for
fighting disease but should rather be asking: how can you be giving so little
to the human condition and so much to the perpetuation of war?
How about the response of the United Nations to HIV/AIDS in Africa?
There is just so much more to be done. Frankly, one of the things that is
inadequate is the United Nations agencies. Some of it is bewildering. For
example, you get the Minister of Health in South Africa (Dr. Manto Tshababala-Msimang)
attacking and dismissing circumcision as a preventive technology. Here you
have three determinative studies, definitive studies, we have UNAIDS and
WHO encouraging male circumcision as a way of reducing transmission and you
get an attack on it by the minister of health in South Africa. Where is the
United Nations' voice? Why haven't they taken on the minister? Why haven't
they said what should be said, which is that she's effectively dooming people
to death and it need not be done? You have to have a much stronger voice
of advocacy from the United Nations in dealing with disease and related matters.
What's going on in Congo, the terrible war on women, the terrible sexual
violence and rape … you have more and more women turning up HIV positive.
Where is the involvement of the United Nations? Where are they on the ground?
Unicef is the only agency that appears to be doing anything of a serious
kind to protect the women or to work with the women on the ground in Congo.
All of these agencies, these ten agencies that are involved in UNAIDS, why…
isn't there an emergency plan being put in? It wasn't the United Nations
that brought down the [antiretroviral] drug prices, it was the Bill Clinton
Foundation… [which did it] by getting the generic drugs from India. Why should
it have been a foundation rather than the world multilateral institution?
So when I say the international community [should do more], I mean above
all the G-8, but I also mean the United Nations itself.
How would you gauge the response of the private sector to HIV/AIDS?
It is very uneven. There are some major multinational corporations that do
good things for their workers. They provide testing, counseling and treatment
and do some work in the community. I honor them for that, salute them for
that. But there are many, many companies in the private sector that refuse
to get involved and won't acknowledge the impact of the virus.
And the private companies have never given to the Global Fund to Fight AIDS,
Tuberculosis and Malaria, what should have been given. I think this year
signaled the first year that there was a significant financial contribution
from a multinational company and that's from Chevron… which has given 30
million dollars over five years. Bono has raised more from the Red Campaign
than has been given by the multinational corporations out of their own philanthropic
envelopes and that's just ugly, frankly.
The multinationals should be much more conscious of their commitment. I've
always believed that they should be giving 0.7 percent of after-tax income
as part of a philanthropic contribution to mirror the target of the governments.
Will you be naming companies specifically as part of your advocacy work,
pointing out which ones that you feel have not contributed sufficiently?
There is no question that we will be challenging the behavior of the private
sector and multinationals. Everybody now uses the phrase "corporate social
responsibility" and that seems regularly to apply to questions of climate
change and global warming. It should equally apply to health and disease.
To what extent might addressing international trade practices have an impact?
If we got a fair international trading regimen, a fair set of property rights
that wouldn't put the profits of pharmaceutical companies above respect for
human life, if we really did forgive all of the debts that should be forgiven,
then countries would have a much greater chance of reaching the Millennium
Development Goals.
The crisis for Africa is compounded by the refusal of the G-8 to achieve
the 0.7 percent of gross national product for foreign aid. As Jeffrey Sachs
has pointed out, if we got to 0.7 percent we would generate a sufficient
amount of foreign aid to be able to meet virtually all of the Millennium
Development Goals… instead of falling so painfully short on everything from
primary school education to maternal mortality and malaria and tuberculosis
and HIV.
The basic problem is dealing with poverty, health and the consequences of
conflict. All of those areas are sabotaged by the refusal to contribute the
foreign aid which we committed ourselves to back in 1970 and have betrayed
now for 30 years, always making promises, always betraying the promises.
I don't want to seem to be a curmudgeon. I don't want to be seen refusing
to acknowledge what has been achieved. Obviously much more is going on than
there was three or four years ago. But I cannot cleanse from my mind the
fact that from 2000 and 2006, when death was so pervasive throughout Africa,
when everything was spiraling out of control as a result of the infection,
the international community responded so very slowly and so pathetically
and inadequately to the carnage that should have triggered an emergency response
and never did, for whatever reason. I don't understand. I'll never understand
it.
Do any countries stand out as shining examples of what other nations should
be doing in the battle against HIV/AIDS and achieving the Millennium Development
Goals?
Norway and the United Kingdom, those two in particular, and France is beginning
to move up the ladder. They really set the example. If the United States
was doing anything comparable to the United Kingdom we'd already be routing
the diseases and the poverty, we'd be reaching the Millennium Development
Goals.
The United Kingdom is moving determinedly towards 0.7 percent by 2013. They've
made that commitment and they're moving towards it. They've got a huge amount
of money, which they're dispensing in every direction. All of it seems to
me to be intelligent. They're funding critical areas and because they have
been increasing the percentage of GDP every year in every budget it's made
a very significant difference.
France is moving towards the 0.7 percent. They have more and more money,
which they're pouring into Francophone Africa.
Norway has just announced this billion dollar program over 10 years for maternal
and child health. Norway's official development assistance is greater than
Canada's, and Canada has 35 million people and Norway has 4.5 million people.
By Cindy Shiner, www.allAfrica.com |
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